洪立方 醫師

Speaker：

洪立方 醫師

Institution：

University of Houston, college of Optometry

Position：

Former senior Research Scientist

Presentation Title：

An update on the role of adenosine receptors in experimental myopia

Abstract：

Adenosine, an endogenic organic compound, exists throughout the entire human body that regulates a multitude of physiological and pathophysiological functions. Previous studies have demonstrated adenosine modulates ocular hemodynamics of aqueous humor, retinal and choroidal blood flow, and neural activities. Our recent reported data with oral administration of 7-methylyxanthine (7-MX) and topical instillation of caffeine showed non-selective adenosine receptor antagonists effectively suppress both lens-induced and form-deprivation myopia. In another experiment, we further identified and reported differential patterns of expression of four adenosine receptors in the ocular tissues of normal non-human primates. These distinct localized subtypes of adenosine receptor illuminate possible underlying anti-myopia mechanisms and brings us one step closer to fully understanding myopia management.